Tricyclic antidepressants for migraine and tension-type headaches

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Tricyclic antidepressants for migraine and tension-type headaches

Tricyclic antidepressants have a long history in the treatment of headache. In 1964 Lance and Curran reported a better response to amitriptyline (30-75 mg/day) in chronic tension headache (n=280) compared with 11 other commonly used drugs (such as benzodiazepines, vasodilators, and sedatives). They also reported a placebo controlled crossover trial of 27 patients that showed clinically signific...

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Tricyclic antidepressants for preventing migraine in adults

BACKGROUND Migraine, ranked as the 7th-highest specific cause of disability worldwide, has caused an enormous burden on the economy and society. Tricyclic antidepressant (TCA) is one of the most commonly drugs for migraine prevention. However, evidence about the efficacy and tolerability of TCAs in the prophylaxis of migraine in adults is somewhat confusing. METHODS A computerized literature ...

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The Prevalence of Migraine and Tension Type Headaches among Epileptic Patients

Background: Headache and epilepsy are two common chronic and recurrent disorders. Headache may be a premonitory or postdromic symptom of epileptic seizures. Objective: This study aims to evaluate the prevalence of migraine and tension type headache in epileptic patients. Materials and Methods: In a cross-sectional descriptive study, 100 patients with epilepsy who referred to the neurology clini...

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Intraerythrocyte antioxidant enzyme activities in migraine and tension-type headaches.

BACKGROUND The pathophysiology of migraine and other headaches is still unknown, and research is mostly done on neurotransmitter, biochemical and vascular mechanisms. The aim of this study was to examine the role of antioxidant enzymes in the pathophysiology of headache in the interictal period of the pain process. METHODS In this study, glutathione peroxidase, catalase and superoxide dismuta...

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Tricyclic antidepressants and headaches: systematic review and meta-analysis

OBJECTIVE To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches. DESIGN Meta-analysis. DATA SOURCES Medline, Embase, the Cochrane Trials Registry, and PsycLIT. Studies reviewed Randomised trials of adults receiving tricyclics as only treatment for a minimum of four weeks. DATA EXTRACTION Frequency...

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ژورنال

عنوان ژورنال: BMJ

سال: 2010

ISSN: 1756-1833

DOI: 10.1136/bmj.c5250